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Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress

1
Department of Basic Medical Sciences, National Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan
2
Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 545; https://doi.org/10.3390/ijms21020545
Received: 26 December 2019 / Accepted: 11 January 2020 / Published: 15 January 2020
(This article belongs to the Special Issue The Nrf2 Pathway: Regulation, Functions, and Potential Applications)
Molecular responses mediated by sensor proteins are important for biological defense against electrophilic stresses, such as xenobiotic electrophile exposure. NF-E2-related factor 2 (Nrf2) has an essential function as a master regulator of such cytoprotective molecular responses along with sensor protein Kelch-like ECH-associated protein 1. This review focuses on Nrf2 activation and its involvement with the protective defense systems under electrophilic stresses integrated with our recent findings that reactive sulfur species (RSS) mediate detoxification of electrophiles. The Nrf2 pathway does not function redundantly with the RSS-generating cystathionine γ-lyase pathway, and vice versa. View Full-Text
Keywords: electrophiles; covalent modification; NF-E2-related factor 2; Kelch-like ECH-associated protein 1; reactive sulfur species; cystathionine γ-lyase electrophiles; covalent modification; NF-E2-related factor 2; Kelch-like ECH-associated protein 1; reactive sulfur species; cystathionine γ-lyase
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MDPI and ACS Style

Unoki, T.; Akiyama, M.; Kumagai, Y. Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress. Int. J. Mol. Sci. 2020, 21, 545.

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