Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase
, Caterina Chiappetta 2, Valentina Ceccarelli 1, Flavia Agata Cimini 1, Laura Bertoccini 1, Melania Gaggini 3, Claudio Di Cristofano 2, Gianfranco Silecchia 2, Andrea Lenzi 1, Frida Leonetti 2, Marco Giorgio Baroni 4,5, Amalia Gastaldelli 3,* and Maria Gisella Cavallo 1,*Round 1
Reviewer 1 Report
The main question addressed in this paper is worth studying and clinically relevant. Thus, the subject and the MS are very original. It enriches our current knowledge in practical implications for every day practice. The paper is elegant, well writtem focused and easy to comprehend. The authors' interpetations and conclusions are sound and based on the arguments and literature provided and aptly discussed. Overall, the readership satnds to gain by this MS.
Reviewer 2 Report
Manuscript presented for review with title: “Angiopoietin-Like Protein 4 overexpression in visceral adipose tissue from obese subjects with impaired glucose metabolism and relationship with Lipoprotein Lipase” is really interesting. The experiment was planned very carefully. The Introduction section includes all necessary information about examined species.
The collected experimental material and used methods do not raise any objections.
The discussion section presents a very good comparison of the obtained results with other results available in the data basis.
The obtained conclusions are clear and in accordance with results.
General opinion: I think, that presented manuscript is a very valuable and should be published in International Journal of Molecular Sciences.
