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Volume 21
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10.3390/ijms21186835
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Review

RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma

by
Jonas Weiße
1,†,
Julia Rosemann
1,†,
Vanessa Krauspe
1,
Matthias Kappler
2,
Alexander W. Eckert
3,
Monika Haemmerle
4 and
Tony Gutschner
1,*
1
Junior Research Group ‘RNA Biology and Pathogenesis’, Medical Faculty, Martin-Luther University Halle-Wittenberg, 06120 Halle/Saale, Germany
2
Department of Oral and Maxillofacial Plastic Surgery, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany
3
Department of Cranio Maxillofacial Surgery, Paracelsus Medical University, 90471 Nuremberg, Germany
4
Institute of Pathology, Section for Experimental Pathology, Medical Faculty, Martin-Luther University Halle-Wittenberg, 06120 Halle/Saale, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(18), 6835; https://doi.org/10.3390/ijms21186835
Submission received: 26 August 2020 / Revised: 14 September 2020 / Accepted: 17 September 2020 / Published: 17 September 2020
(This article belongs to the Special Issue RNA-Binding Proteins in Human Diseases—from Mechanisms to Therapies)
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Abstract

Nearly 7.5% of all human protein-coding genes have been assigned to the class of RNA-binding proteins (RBPs), and over the past decade, RBPs have been increasingly recognized as important regulators of molecular and cellular homeostasis. RBPs regulate the post-transcriptional processing of their target RNAs, i.e., alternative splicing, polyadenylation, stability and turnover, localization, or translation as well as editing and chemical modification, thereby tuning gene expression programs of diverse cellular processes such as cell survival and malignant spread. Importantly, metastases are the major cause of cancer-associated deaths in general, and particularly in oral cancers, which account for 2% of the global cancer mortality. However, the roles and architecture of RBPs and RBP-controlled expression networks during the diverse steps of the metastatic cascade are only incompletely understood. In this review, we will offer a brief overview about RBPs and their general contribution to post-transcriptional regulation of gene expression. Subsequently, we will highlight selected examples of RBPs that have been shown to play a role in oral cancer cell migration, invasion, and metastasis. Last but not least, we will present targeting strategies that have been developed to interfere with the function of some of these RBPs.
Keywords: HNSCC; oral cancer; OSCC; RBP; IGF2BP3; LIN28; HuR; METTL3; DDX3 HNSCC; oral cancer; OSCC; RBP; IGF2BP3; LIN28; HuR; METTL3; DDX3

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MDPI and ACS Style

Weiße, J.; Rosemann, J.; Krauspe, V.; Kappler, M.; Eckert, A.W.; Haemmerle, M.; Gutschner, T. RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma. Int. J. Mol. Sci. 2020, 21, 6835. https://doi.org/10.3390/ijms21186835

AMA Style

Weiße J, Rosemann J, Krauspe V, Kappler M, Eckert AW, Haemmerle M, Gutschner T. RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences. 2020; 21(18):6835. https://doi.org/10.3390/ijms21186835

Chicago/Turabian Style

Weiße, Jonas, Julia Rosemann, Vanessa Krauspe, Matthias Kappler, Alexander W. Eckert, Monika Haemmerle, and Tony Gutschner. 2020. "RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma" International Journal of Molecular Sciences 21, no. 18: 6835. https://doi.org/10.3390/ijms21186835

APA Style

Weiße, J., Rosemann, J., Krauspe, V., Kappler, M., Eckert, A. W., Haemmerle, M., & Gutschner, T. (2020). RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences, 21(18), 6835. https://doi.org/10.3390/ijms21186835

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