Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases
Abstract
:1. Introduction: The Concepts: Iso and Allo-Convergent Evolution, Evolutionary Shift, and Maintenance of Apomorphies
2. Enzyme Convergent Evolution via Allo-Convergent and Iso-Convergent Evolution: The Case of β-Lactamases
2.1. Allo-Convergent Evolution of Enzyme Function: The Case of β-Lactamases
2.2. Iso-Convergent Evolution of the Metallo-β-Lactamases Functional Family
Evolutionary Analyses of the Metallo-β-Lactamases Family
2.3. Evolution of the Metallo-β-Lactamase Activity via an Increase in the Probability of Shift and Fixation of the New Character
2.4. The Metallo-β-Lactamases Evolved via Iso-Convergent Evolution Because Possibly Also of Positive Selection
2.5. Iso-Convergent Evolution of the Serine β-Lactamase Family
2.6. Hypothesis: Allo-Convergent Evolution Should Be Linked to Iso-Convergent Evolution
3. Materials and Methods
3.1. Sequence Selection
3.2. Functional Domain Identifications
3.3. Phylogenetic Tree Construction
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Keshri, V.; Chabrière, E.; Pinault, L.; Colson, P.; Diene, S.M.; Rolain, J.-M.; Raoult, D.; Pontarotti, P. Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases. Int. J. Mol. Sci. 2020, 21, 6260. https://doi.org/10.3390/ijms21176260
Keshri V, Chabrière E, Pinault L, Colson P, Diene SM, Rolain J-M, Raoult D, Pontarotti P. Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases. International Journal of Molecular Sciences. 2020; 21(17):6260. https://doi.org/10.3390/ijms21176260
Chicago/Turabian StyleKeshri, Vivek, Eric Chabrière, Lucile Pinault, Philippe Colson, Seydina M Diene, Jean-Marc Rolain, Didier Raoult, and Pierre Pontarotti. 2020. "Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases" International Journal of Molecular Sciences 21, no. 17: 6260. https://doi.org/10.3390/ijms21176260