Next Article in Journal
Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae
Next Article in Special Issue
The Cruciality of Single Amino Acid Replacement for the Spectral Tuning of Biliverdin-Binding Cyanobacteriochromes
Previous Article in Journal
ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation
Previous Article in Special Issue
Physicochemical Evidence that Francisella FupA and FupB Proteins Are Porins
Review

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

1
Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada
2
Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo City, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6197; https://doi.org/10.3390/ijms21176197
Received: 29 July 2020 / Revised: 17 August 2020 / Accepted: 24 August 2020 / Published: 27 August 2020
Neurotransmission between neurons, which can occur over the span of a few milliseconds, relies on the controlled release of small molecule neurotransmitters, many of which are amino acids. Fluorescence imaging provides the necessary speed to follow these events and has emerged as a powerful technique for investigating neurotransmission. In this review, we highlight some of the roles of the 20 canonical amino acids, GABA and β-alanine in neurotransmission. We also discuss available fluorescence-based probes for amino acids that have been shown to be compatible for live cell imaging, namely those based on synthetic dyes, nanostructures (quantum dots and nanotubes), and genetically encoded components. We aim to provide tool developers with information that may guide future engineering efforts and tool users with information regarding existing indicators to facilitate studies of amino acid dynamics. View Full-Text
Keywords: amino acids; neurotransmission; fluorescence; imaging; biosensors; neurotransmitters; indicators amino acids; neurotransmission; fluorescence; imaging; biosensors; neurotransmitters; indicators
Show Figures

Figure 1

MDPI and ACS Style

Dalangin, R.; Kim, A.; Campbell, R.E. The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection. Int. J. Mol. Sci. 2020, 21, 6197. https://doi.org/10.3390/ijms21176197

AMA Style

Dalangin R, Kim A, Campbell RE. The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection. International Journal of Molecular Sciences. 2020; 21(17):6197. https://doi.org/10.3390/ijms21176197

Chicago/Turabian Style

Dalangin, Rochelin, Anna Kim, and Robert E. Campbell 2020. "The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection" International Journal of Molecular Sciences 21, no. 17: 6197. https://doi.org/10.3390/ijms21176197

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop