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Volume 21
Issue 17
10.3390/ijms21176150
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Review
Peer-Review Record

Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis

Int. J. Mol. Sci. 2020, 21(17), 6150; https://doi.org/10.3390/ijms21176150
by Kathryn Hally 1,2,3,*, Sebastien Fauteux-Daniel 4,5, Hind Hamzeh-Cognasse 5, Peter Larsen 1,2,† and Fabrice Cognasse 4,5,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(17), 6150; https://doi.org/10.3390/ijms21176150
Submission received: 15 July 2020 / Revised: 19 August 2020 / Accepted: 21 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Molecular Research on Platelet Activity in Health and Disease 2.0)

Round 1

Reviewer 1 Report

the review by Hally et al presents an up to date coverage of the role of Toll-like recptors in platelets and their role in vascular immunity and thrombosis. overall the review is comprehensive in its coverage and a useful toll re understanding the role of platelets in inflammation.

Given the overall effects of haemodynamics and pathological shear stress on platelet thrombotic function a section covering known impacts of blood flow mechanics on platelet to leukocyte/monocyte interactions and effects on TLR signalling might be useful.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

In this manuscript, Hally et al. reviewed the function of the different TLRs in platelets. This is a very interesting topic. The review is very complete, well written and documented, and very easy to follow. This is an excellent and necessary review that can help both basic scientist and clinicians. A special mention to figures and tables that are very useful. I just have some comments in relation with two aspects that were not treated, regulation and therapy.

  1. Authors should detail in the Supplementary Tables referencing platelet functional tests, the agonists used and the concentration range.
  2. TLR expression and function may be modulated by SNPs or ncRNAs such as miRNAs among other. The authors should add a paragraph on the regulation of TLRs and discuss the impact in the pathophysiology of diseases related with platelet function.
  3. A short paragraph on therapeutics targeting TLR could be of interest in the context of their role in platelets.
  4. Paragraph 2.4 has to be more specific and explain better how platelets can moderate inflammatory processes.
  5. Lines 146-147: TLR5 is included in both of the groups described. Is it a typo error?

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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