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Review

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

1
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, Italy
2
Centre for Applied Biomedical Research (CRBA), Bologna University Hospital Authority St. Orsola-Malpighi Polyclinic, 40138 Bologna, Italy
3
Department of Oncology, Policlinico S. Orsola-Malpighi, University of Bologna, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(17), 6009; https://doi.org/10.3390/ijms21176009
Received: 11 July 2020 / Revised: 4 August 2020 / Accepted: 18 August 2020 / Published: 20 August 2020
(This article belongs to the Special Issue Regulation of Inflammatory Reactions in Health and Disease)
IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing the tumor microenvironment and promoting cancer initiation and progression. Thus, it orchestrates immunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recent findings showed that this cytokine can be directly produced by tumor cells in a positive feedback loop and contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated. View Full-Text
Keywords: IL-1; cancer; resistance IL-1; cancer; resistance
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MDPI and ACS Style

Gelfo, V.; Romaniello, D.; Mazzeschi, M.; Sgarzi, M.; Grilli, G.; Morselli, A.; Manzan, B.; Rihawi, K.; Lauriola, M. Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies. Int. J. Mol. Sci. 2020, 21, 6009. https://doi.org/10.3390/ijms21176009

AMA Style

Gelfo V, Romaniello D, Mazzeschi M, Sgarzi M, Grilli G, Morselli A, Manzan B, Rihawi K, Lauriola M. Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies. International Journal of Molecular Sciences. 2020; 21(17):6009. https://doi.org/10.3390/ijms21176009

Chicago/Turabian Style

Gelfo, Valerio, Donatella Romaniello, Martina Mazzeschi, Michela Sgarzi, Giada Grilli, Alessandra Morselli, Beatrice Manzan, Karim Rihawi, and Mattia Lauriola. 2020. "Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies" International Journal of Molecular Sciences 21, no. 17: 6009. https://doi.org/10.3390/ijms21176009

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