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Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

1
Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam
2
Department of Botany, Government Science College, Pandhurna, Chhindwara, Madhya Pradesh 480334, India
3
Department of Physical Therapy, Asia University, Taichung 41354, Taiwan
4
Department of Physical Therapy Graduate Institute of Rehabilitation Science, China Medical University, Taichung 40402, Taiwan
5
Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5895; https://doi.org/10.3390/ijms21165895
Received: 29 July 2020 / Revised: 13 August 2020 / Accepted: 15 August 2020 / Published: 16 August 2020
(This article belongs to the Special Issue Neuroprotective Strategies 2020)
Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasympathetic nervous system (PNS), Autonomic Nervous System (ANS) and central nervous system (CNS) by promoting many processes such as synaptic plasticity, neurogenesis, angiogenesis, and autophagy. Overall, it carries out many protective and preventive activities such as improvements in memory, cognition, sleep and mood; growth of new blood vessels in nervous system; and the reduction of stress, anxiety, neuro-inflammation, and insulin resistance. In the present work, the protective effects of PE were overviewed. Suitable examples from the current research work in this context are also given in the article. View Full-Text
Keywords: Alzheimer’s disease; anti-inflammation; antioxidant; Irisin; neurodegenerative diseases; Parkinson’s disease; physical exercise Alzheimer’s disease; anti-inflammation; antioxidant; Irisin; neurodegenerative diseases; Parkinson’s disease; physical exercise
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Mahalakshmi, B.; Maurya, N.; Lee, S.-D.; Bharath Kumar, V. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration. Int. J. Mol. Sci. 2020, 21, 5895.

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