Epigenetic Mechanisms of Inflammasome Regulation
Abstract
:1. Introduction
2. Epigenetic Modifications
3. Inflammasomes and Inflammasome-Associated Diseases
4. Epigenetic Regulation of the Inflammasome
5. Role of Noncoding RNA in the Regulation of Inflammasome
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AIM | Absent in melanoma 2 |
ALI | Acute lung injury |
ASC | Apoptosis-associated speck-like protein containing a CARD |
CAPS | Cryopyrin-associated periodic syndromes |
CCL | Chemokine C-C motif ligand |
COX | Cyclooxygenase |
DAMPs | Danger associated molecular patterns |
FMF | Familial Mediterranean fever |
HDAC | Histone deacetylase |
IFI | Interferon-γ inducible factor |
IL-1β | Interleukin-1β |
JMJD3 | Histone demethylase Jumonji domain-containing 3 |
LNC RNAs | Long noncoding RNAs |
LPS | Lipopolysaccharide |
NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
NLR | Nucleotide-binding oligomerization domain, Nod-like receptor |
NLRC4 | NLR family, CARD domain containing 4 |
PAMPs | Pathogen-associated molecular patterns |
PD | Parkinson’s disease |
PRRs | Pattern recognition receptors |
PTMs | Histones post-translational modifications |
PYD | Pyrin domain |
TLRs | Toll-like receptors |
TMS1 | Target of methylation-induced silencing-1 |
TNF | Tumor necrosis factor |
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miRNA | Target Gene | Disease | References |
---|---|---|---|
miR-223 | NLRP3 | Inflammatory bowel diseases | [102] |
Acute lung injury/acute respiratory distress syndrome | [103] | ||
Hepatocellular carcinoma | [104] | ||
miR-133a | NLRP3 | Inflammatory diseases | [105] |
miR-22 | NLRP3 | Gastric cancer | [106] |
miR-30e | NLRP3 | Parkinson’s disease | [107] |
miR-7 | NLRP3 | Parkinson’s disease | [108] |
miR-199a-3p | NLRP1 | Acute Lung Injury | [109] |
miR-146a-5p | NLRP3 | Autoimmune diseases, Multiple sclerosis | [110] |
miR-20b-5p | NLRP3 | Multiple sclerosis | [4] |
miR-495-3p | NLRP3 | Cardiac injury | [111] |
miR-330-3p | NLRP3 | Renal inflammatory disease | [112] |
mir-17-5p | NLRP3 | Obesity disease | [113] |
mir-141-3p | NLRP3; NLRP4 | Bladder cancer | [114] |
miR-372 | NLRP12 | Ulcerative Colitis | [115] |
miR-143 | AIM2 | Inflammatory diseases | [116] |
miR-18b | NLRP7 | Breast cancer | [117] |
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Poli, G.; Fabi, C.; Bellet, M.M.; Costantini, C.; Nunziangeli, L.; Romani, L.; Brancorsini, S. Epigenetic Mechanisms of Inflammasome Regulation. Int. J. Mol. Sci. 2020, 21, 5758. https://doi.org/10.3390/ijms21165758
Poli G, Fabi C, Bellet MM, Costantini C, Nunziangeli L, Romani L, Brancorsini S. Epigenetic Mechanisms of Inflammasome Regulation. International Journal of Molecular Sciences. 2020; 21(16):5758. https://doi.org/10.3390/ijms21165758
Chicago/Turabian StylePoli, Giulia, Consuelo Fabi, Marina Maria Bellet, Claudio Costantini, Luisa Nunziangeli, Luigina Romani, and Stefano Brancorsini. 2020. "Epigenetic Mechanisms of Inflammasome Regulation" International Journal of Molecular Sciences 21, no. 16: 5758. https://doi.org/10.3390/ijms21165758