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The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside
Open AccessReview

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

1
Second Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-809 Warsaw, Poland
2
Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA
3
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt
4
Second Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5528; https://doi.org/10.3390/ijms21155528
Received: 24 June 2020 / Revised: 27 July 2020 / Accepted: 30 July 2020 / Published: 1 August 2020
(This article belongs to the Special Issue Therapeutic Molecular Targets in Tumor Microenvironment)
Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology. View Full-Text
Keywords: uterine fibroid; leiomyoma; pathophysiology; vitamins; vitamin A; vitamin B3; vitamin C; vitamin D; vitamin E; vitamin K uterine fibroid; leiomyoma; pathophysiology; vitamins; vitamin A; vitamin B3; vitamin C; vitamin D; vitamin E; vitamin K
MDPI and ACS Style

Ciebiera, M.; Ali, M.; Zgliczyńska, M.; Skrzypczak, M.; Al-Hendy, A. Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. Int. J. Mol. Sci. 2020, 21, 5528.

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