Next Article in Journal
Targeting Epigenetic Modifications in Uveal Melanoma
Next Article in Special Issue
Function of Platelet Glycosphingolipid Microdomains/Lipid Rafts
Previous Article in Journal
Deubiquitination Reactions on the Proteasome for Proteasome Versatility
Previous Article in Special Issue
Isolation and Characterization of Antibodies Induced by Immunization with TNF-α Inducible Globotetraosylceramide
Open AccessReview

Gangliosides and Neuroblastomas

Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Int. J. Mol. Sci. 2020, 21(15), 5313;
Received: 11 May 2020 / Revised: 9 July 2020 / Accepted: 18 July 2020 / Published: 27 July 2020
(This article belongs to the Special Issue Roles of Glycosphingolipids in Metabolism)
The focus of this review is the ganglio-series of glycosphingolipids found in neuroblastoma (NB) and the myriad of unanswered questions associated with their possible role(s) in this cancer. NB is one of the more common solid malignancies of children. Five-year survival for those diagnosed with low risk NB is 90–95%, while that for children with high-risk NB is around 40–50%. Much of the survival rate reflects age of diagnosis with children under a year having a much better prognosis than those over two. Identification of expression of GD2 on the surface of most NB cells led to studies of the effectiveness and subsequent approval of anti-GD2 antibodies as a treatment modality. Despite much success, a subset of patients, possibly those whose tumors fail to express concentrations of gangliosides such as GD1b and GT1b found in tumors from patients with a good prognosis, have tumors refractory to treatment. These observations support discussion of what is known about control of ganglioside synthesis, and their actual functions in NB, as well as their possible relationship to treatment response. View Full-Text
Keywords: ganglioside; neuroblastoma; glycosyltransferases; glycosidases ganglioside; neuroblastoma; glycosyltransferases; glycosidases
Show Figures

Graphical abstract

MDPI and ACS Style

Schengrund, C.-L. Gangliosides and Neuroblastomas. Int. J. Mol. Sci. 2020, 21, 5313.

AMA Style

Schengrund C-L. Gangliosides and Neuroblastomas. International Journal of Molecular Sciences. 2020; 21(15):5313.

Chicago/Turabian Style

Schengrund, Cara-Lynne. 2020. "Gangliosides and Neuroblastomas" Int. J. Mol. Sci. 21, no. 15: 5313.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop