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The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
Chemistry Department, Faculty of Sciences and Technology, University of Coimbra, 3004-535 Coimbra, Portugal
Thyroid Study Group, Portuguese Society of Endocrinology, Diabetes and Metabolism, 1600-892 Lisbon, Portugal
EPIUnit-Institute of Public Health, University of Porto, 4050-600 Porto, Portugal
Department of Chemistry and CICECO, University of Aveiro, 3810-193 Aveiro, Portugal
Department of Biomedical Sciences, University of Cagliari, 09042 Cagliari, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5272;
Received: 16 June 2020 / Revised: 20 July 2020 / Accepted: 22 July 2020 / Published: 24 July 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics. View Full-Text
Keywords: metabolomics; thyroid cancer; biomarker; metabolite; diagnosis metabolomics; thyroid cancer; biomarker; metabolite; diagnosis
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MDPI and ACS Style

Coelho, M.; Raposo, L.; Goodfellow, B.J.; Atzori, L.; Jones, J.; Manadas, B. The Potential of Metabolomics in the Diagnosis of Thyroid Cancer. Int. J. Mol. Sci. 2020, 21, 5272.

AMA Style

Coelho M, Raposo L, Goodfellow BJ, Atzori L, Jones J, Manadas B. The Potential of Metabolomics in the Diagnosis of Thyroid Cancer. International Journal of Molecular Sciences. 2020; 21(15):5272.

Chicago/Turabian Style

Coelho, Margarida, Luis Raposo, Brian J. Goodfellow, Luigi Atzori, John Jones, and Bruno Manadas. 2020. "The Potential of Metabolomics in the Diagnosis of Thyroid Cancer" International Journal of Molecular Sciences 21, no. 15: 5272.

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