Next Article in Journal
Family’s History Based on the CDH1 Germline Variant (c.360delG) and a Suspected Hereditary Gastric Cancer Form
Previous Article in Journal
SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 14
10.3390/ijms21144903
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

by
Elena Campione
1,*,
Terenzio Cosio
1,
Luigi Rosa
2,
Caterina Lanna
1,
Stefano Di Girolamo
3,
Roberta Gaziano
4,
Piera Valenti
2,† and
Luca Bianchi
1,†
1
Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
2
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy
3
Department of Otorhinolaryngology, University of Rome Tor Vergata, 00133 Rome, Italy
4
Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(14), 4903; https://doi.org/10.3390/ijms21144903
Submission received: 17 June 2020 / Revised: 5 July 2020 / Accepted: 9 July 2020 / Published: 11 July 2020
(This article belongs to the Section Molecular Microbiology)
Browse Figure
Versions Notes

Abstract

Recently, the world has been dealing with a devastating global pandemic coronavirus infection, with more than 12 million infected worldwide and over 300,000 deaths as of May 15th 2020, related to a novel coronavirus (2019-nCoV), characterized by a spherical morphology and identified through next-generation sequencing. Although the respiratory tract is the primary portal of entry of SARS-CoV-2, gastrointestinal involvement associated with nausea, vomiting and diarrhoea may also occur. No drug or vaccine has been approved due to the absence of evidence deriving from rigorous clinical trials. Increasing interest has been highlighted on the possible preventative role and adjunct treatment of lactoferrin, glycoprotein of human secretions part of a non-specific defensive system, known to play a crucial role against microbial and viral infections and exerting anti-inflammatory effects on different mucosal surfaces and able to regulate iron metabolism. In this review, analysing lactoferrin properties, we propose designing a clinical trial to evaluate and verify its effect using a dual combination treatment with local, solubilized intranasal spray formulation and oral administration. Lactoferrin could counteract the coronavirus infection and inflammation, acting either as natural barrier of both respiratory and intestinal mucosa or reverting the iron disorders related to the viral colonization.
Keywords: coronavirus; SARS; lactoferrin coronavirus; SARS; lactoferrin

Share and Cite

MDPI and ACS Style

Campione, E.; Cosio, T.; Rosa, L.; Lanna, C.; Di Girolamo, S.; Gaziano, R.; Valenti, P.; Bianchi, L. Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation. Int. J. Mol. Sci. 2020, 21, 4903. https://doi.org/10.3390/ijms21144903

AMA Style

Campione E, Cosio T, Rosa L, Lanna C, Di Girolamo S, Gaziano R, Valenti P, Bianchi L. Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation. International Journal of Molecular Sciences. 2020; 21(14):4903. https://doi.org/10.3390/ijms21144903

Chicago/Turabian Style

Campione, Elena, Terenzio Cosio, Luigi Rosa, Caterina Lanna, Stefano Di Girolamo, Roberta Gaziano, Piera Valenti, and Luca Bianchi. 2020. "Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation" International Journal of Molecular Sciences 21, no. 14: 4903. https://doi.org/10.3390/ijms21144903

APA Style

Campione, E., Cosio, T., Rosa, L., Lanna, C., Di Girolamo, S., Gaziano, R., Valenti, P., & Bianchi, L. (2020). Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation. International Journal of Molecular Sciences, 21(14), 4903. https://doi.org/10.3390/ijms21144903

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop