Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer
Abstract
1. Introduction
2. Results
2.1. Antiproliferative Effect
2.2. Morphological Changes
2.3. Induction of Oxidative Stress
2.4. Induction of DNA Damage
2.5. Induction of Cell Cycle Arrest
3. Discussion
3.1. Antiproliferative Effect
3.2. Induction of Oxidative Stress
3.3. Induction of DNA Damage
3.4. Induction of Cell Cycle Arrest
4. Materials and Methods
4.1. Chemicals and Media
4.2. Vernonia calvoana Preparation and Fractionation
4.3. Cell Culture
4.4. Cell Treatment and Determination of Cell Viability
4.5. Morphological Changes
4.6. Measurement of Lipid Peroxidation/Malondiadehyde
4.7. Measurement of Catalase Activity
4.8. Measurement of Glutathione Peroxidase Activity
4.9. Assessment of DNA Damage
4.10. Assessment of Cell Cycle Distribution
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Mbemi, A.T.; Sims, J.N.; Yedjou, C.G.; Noubissi, F.K.; Gomez, C.R.; Tchounwou, P.B. Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer. Int. J. Mol. Sci. 2020, 21, 4429. https://doi.org/10.3390/ijms21124429
Mbemi AT, Sims JN, Yedjou CG, Noubissi FK, Gomez CR, Tchounwou PB. Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer. International Journal of Molecular Sciences. 2020; 21(12):4429. https://doi.org/10.3390/ijms21124429
Chicago/Turabian StyleMbemi, Ariane T., Jennifer N. Sims, Clement G. Yedjou, Felicite K. Noubissi, Christian R. Gomez, and Paul B. Tchounwou. 2020. "Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer" International Journal of Molecular Sciences 21, no. 12: 4429. https://doi.org/10.3390/ijms21124429
APA StyleMbemi, A. T., Sims, J. N., Yedjou, C. G., Noubissi, F. K., Gomez, C. R., & Tchounwou, P. B. (2020). Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer. International Journal of Molecular Sciences, 21(12), 4429. https://doi.org/10.3390/ijms21124429