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Three Method-Combination Protocol for Improving Purity of Extracellular Vesicles
Open AccessReview

Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC)

by Eliane Ebnoether 1,2 and Laurent Muller 1,2,*
1
Department of Biomedicine, University of Basel, 4031 Basel, Switzerland
2
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, 4051 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4344; https://doi.org/10.3390/ijms21124344
Received: 18 May 2020 / Revised: 10 June 2020 / Accepted: 12 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics)
Exosomes are nanovesicles part of a recently described intercellular communication system. Their properties seem promising as a biomarker in cancer research, where more sensitive monitoring and therapeutic applications are desperately needed. In the case of head and neck squamous cell carcinoma (HNSCC), overall survival often remains poor, although huge technological advancements in the treatment of this disease have been made. In the following review, diagnostic and therapeutic properties are highlighted and summarised. Impressive first results have been obtained but more research is needed to implement these innovative techniques into daily clinical routines. View Full-Text
Keywords: head and neck squamous cell carcinoma (HNSCC); exosomes; cancer; biomarker; diagnostic; therapy; liquid biopsy head and neck squamous cell carcinoma (HNSCC); exosomes; cancer; biomarker; diagnostic; therapy; liquid biopsy
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Ebnoether, E.; Muller, L. Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC). Int. J. Mol. Sci. 2020, 21, 4344.

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