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Review

Neuronal Reprogramming for Tissue Repair and Neuroregeneration

1
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia
2
Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC 3002, Australia
3
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4273; https://doi.org/10.3390/ijms21124273
Received: 8 May 2020 / Revised: 8 June 2020 / Accepted: 8 June 2020 / Published: 16 June 2020
(This article belongs to the Special Issue Role of Gene Expression in the Physiology and Pathology of Neurons)
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive specific neuronal cell types for therapeutic applications. Both in vitro and in vivo cellular reprogramming provide diverse therapeutic pathways for modeling neurological diseases and injury repair. In particular, the retina has emerged as a promising target for clinical application of regenerative medicine. Herein, we review the potential of neuronal reprogramming to develop regenerative strategy, with a particular focus on treating retinal degenerative diseases and discuss future directions and challenges in the field. View Full-Text
Keywords: cell reprogramming; pluripotent stem cells; retina; neuroregeneration cell reprogramming; pluripotent stem cells; retina; neuroregeneration
MDPI and ACS Style

Liou, R.H.-C.; Edwards, T.L.; Martin, K.R.; Wong, R.C.-B. Neuronal Reprogramming for Tissue Repair and Neuroregeneration. Int. J. Mol. Sci. 2020, 21, 4273. https://doi.org/10.3390/ijms21124273

AMA Style

Liou RH-C, Edwards TL, Martin KR, Wong RC-B. Neuronal Reprogramming for Tissue Repair and Neuroregeneration. International Journal of Molecular Sciences. 2020; 21(12):4273. https://doi.org/10.3390/ijms21124273

Chicago/Turabian Style

Liou, Roxanne H.-C.; Edwards, Thomas L.; Martin, Keith R.; Wong, Raymond C.-B. 2020. "Neuronal Reprogramming for Tissue Repair and Neuroregeneration" Int. J. Mol. Sci. 21, no. 12: 4273. https://doi.org/10.3390/ijms21124273

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