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Review

Efflux Pump Inhibitors against Nontuberculous Mycobacteria

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, I-56127 Pisa, Italy
Int. J. Mol. Sci. 2020, 21(12), 4191; https://doi.org/10.3390/ijms21124191
Received: 28 May 2020 / Revised: 9 June 2020 / Accepted: 10 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue New Drugs and Novel Strategies against Nontuberculous Mycobacteria)
Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections. Efflux pumps (EPs) are important elements that are involved in drug resistance by preventing intracellular accumulation of antibiotics. A promising strategy to decrease drug resistance is the inhibition of EP activity by EP inhibitors (EPIs), compounds that are able to increase the intracellular concentration of antimicrobials. Recently, attention has been focused on identifying EPIs in mycobacteria that could be used in combination with drugs. The aim of the present review is to provide an overview of the current knowledge on EPs and EPIs in NTM and also, the effect of potential EPIs as well as their combined use with antimycobacterial drugs in various NTM species are described. View Full-Text
Keywords: efflux pump inhibitor; nontuberculous mycobacteria; drug resistance; Mycobacterium avium complex; Mycobacterium abscessus efflux pump inhibitor; nontuberculous mycobacteria; drug resistance; Mycobacterium avium complex; Mycobacterium abscessus
MDPI and ACS Style

Rindi, L. Efflux Pump Inhibitors against Nontuberculous Mycobacteria. Int. J. Mol. Sci. 2020, 21, 4191. https://doi.org/10.3390/ijms21124191

AMA Style

Rindi L. Efflux Pump Inhibitors against Nontuberculous Mycobacteria. International Journal of Molecular Sciences. 2020; 21(12):4191. https://doi.org/10.3390/ijms21124191

Chicago/Turabian Style

Rindi, Laura. 2020. "Efflux Pump Inhibitors against Nontuberculous Mycobacteria" International Journal of Molecular Sciences 21, no. 12: 4191. https://doi.org/10.3390/ijms21124191

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