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Open AccessReview

Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis

1
Graduate Program in Biotechnology and Biodiversity in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil
2
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil
3
Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 4093; https://doi.org/10.3390/ijms21114093
Received: 9 March 2020 / Revised: 27 March 2020 / Accepted: 27 March 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Role of Nutraceuticals in Metabolic and Gastrointestinal Disorders)
Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n–3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts. View Full-Text
Keywords: health; short-chain fatty acids; intestinal bacteria; hypertension; inflammatory diseases; diabetes health; short-chain fatty acids; intestinal bacteria; hypertension; inflammatory diseases; diabetes
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MDPI and ACS Style

Machate, D.J.; Figueiredo, P.S.; Marcelino, G.; Guimarães, R.d.C.A.; Hiane, P.A.; Bogo, D.; Pinheiro, V.A.Z.; Oliveira, L.C.S.d.; Pott, A. Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis. Int. J. Mol. Sci. 2020, 21, 4093. https://doi.org/10.3390/ijms21114093

AMA Style

Machate DJ, Figueiredo PS, Marcelino G, Guimarães RdCA, Hiane PA, Bogo D, Pinheiro VAZ, Oliveira LCSd, Pott A. Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis. International Journal of Molecular Sciences. 2020; 21(11):4093. https://doi.org/10.3390/ijms21114093

Chicago/Turabian Style

Machate, David J.; Figueiredo, Priscila S.; Marcelino, Gabriela; Guimarães, Rita d.C.A.; Hiane, Priscila A.; Bogo, Danielle; Pinheiro, Verônica A.Z.; Oliveira, Lincoln C.S.d.; Pott, Arnildo. 2020. "Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis" Int. J. Mol. Sci. 21, no. 11: 4093. https://doi.org/10.3390/ijms21114093

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