Genetically Modified Mesenchymal Stem Cells: The Next Generation of Stem Cell-Based Therapy for TBI
, Chung-Che Wu 3,4,5,6, Yung-Hsiao Chiang 2,3,4,5,6,* and Kai-Yun Chen 2,3,4,*
Round 1
Reviewer 1 Report
Very nice article and excellent images.
1) I would suggest to modify the title of subsection 3 as "Neuroinflammatory Cascade of TBI"
2) Given the rather innovative and theranostic perspective of this article I would recommend to add the following paper to the reference list:
Ganau L, Prisco L, Ligarotti GKI, Ambu R, Ganau M. Understanding the pathological basis of neurological diseases through diagnostic platforms based on innovations in biomedical engineering: new concepts and theranostic perspectives. Medicines (Basel). 2018;5(1):22. doi: 10.3390/medicines5010022.Author Response
We appreciate the invaluable reviewer’s comments on revising our manuscript. We thank the reviewer for giving this study merit. Please find below the reviewer's comments in italic, followed by our detailed responses and revisions. We have revised accordingly in response to reviewers’ suggestions. We hope it is now suitable for publication in IJMS
1) I would suggest to modify the title of subsection 3 as "Neuroinflammatory Cascade of TBI"
Response: We have revised the main text and modified the title of mentioned subsection the as "Neuroinflammatory Cascade of TBI"
2) Given the rather innovative and theranostic perspective of this article I would recommend to add the following paper to the reference list:
Ganau L, Prisco L, Ligarotti GKI, Ambu R, Ganau M. Understanding the pathological basis of neurological diseases through diagnostic platforms based on innovations in biomedical engineering: new concepts and theranostic perspectives. Medicines (Basel). 2018;5(1):22. doi: 10.3390/medicines5010022.
Response: We thank the reviewer's interest to enhance the manuscript by adding interesting and innovative literature such as the recommended. We cited the recommended reference for further discussing the innovative and theranostic perspective role in TBI therapy and diagnosis
Reviewer 2 Report
Congratulations on the work with MSCs to mitigate TBI, and then writing this informative well illustrated review. See suggestion in Word Doc as comments. Write without use of "we". Writing in active voice without self reference makes reader focus on topic.
Comments for author File: 
Comments.pdf
Author Response
We appreciate the invaluable reviewer’s comments on revising our manuscript. Please find below the reviewer's comments in italic, followed by our detailed responses and revisions. We have revised accordingly in response to reviewers’ suggestions. We hope it is now suitable for publication in IJMS
1) Congratulations on the work with MSCs to mitigate TBI, and then writing this informative well illustrated review. See suggestion in Word Doc as comments. Write without use of "we". Writing in active voice without self reference makes reader focus on topic.
Response: We thank the reviewer for giving this study merit and for your invaluable comments and suggestions. We have revised the main text and rewrite it without the "we". We also followed. We also addressed you comment and followed your suggestions in the main text.
