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Review

The Emerging Role of Innate Immunity in Chronic Kidney Diseases

by
Philip Chiu-Tsun Tang
1,†,
Ying-Ying Zhang
2,†,
Max Kam-Kwan Chan
1,
Winson Wing-Yin Lam
1,
Jeff Yat-Fai Chung
1,
Wei Kang
1,
Ka-Fai To
1,
Hui-Yao Lan
3 and
Patrick Ming-Kuen Tang
1,*
1
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, China
2
Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
3
Li Ka Shing Institute of Health Sciences, and Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong 999077, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(11), 4018; https://doi.org/10.3390/ijms21114018
Submission received: 1 April 2020 / Revised: 28 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
(This article belongs to the Special Issue Immune Cell Mediated Tissue Regeneration)
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Abstract

Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of both clinical and experimental information, focused on how innate immune signaling contributes to renal fibrogenesis. A better understanding of the underlying mechanisms may uncover a novel therapeutic strategy for ESRD.
Keywords: chronic kidney disease; microenvironment; kidney fibrosis; macrophage–myofibroblast transition; inflammation chronic kidney disease; microenvironment; kidney fibrosis; macrophage–myofibroblast transition; inflammation
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MDPI and ACS Style

Tang, P.C.-T.; Zhang, Y.-Y.; Chan, M.K.-K.; Lam, W.W.-Y.; Chung, J.Y.-F.; Kang, W.; To, K.-F.; Lan, H.-Y.; Tang, P.M.-K. The Emerging Role of Innate Immunity in Chronic Kidney Diseases. Int. J. Mol. Sci. 2020, 21, 4018. https://doi.org/10.3390/ijms21114018

AMA Style

Tang PC-T, Zhang Y-Y, Chan MK-K, Lam WW-Y, Chung JY-F, Kang W, To K-F, Lan H-Y, Tang PM-K. The Emerging Role of Innate Immunity in Chronic Kidney Diseases. International Journal of Molecular Sciences. 2020; 21(11):4018. https://doi.org/10.3390/ijms21114018

Chicago/Turabian Style

Tang, Philip Chiu-Tsun, Ying-Ying Zhang, Max Kam-Kwan Chan, Winson Wing-Yin Lam, Jeff Yat-Fai Chung, Wei Kang, Ka-Fai To, Hui-Yao Lan, and Patrick Ming-Kuen Tang. 2020. "The Emerging Role of Innate Immunity in Chronic Kidney Diseases" International Journal of Molecular Sciences 21, no. 11: 4018. https://doi.org/10.3390/ijms21114018

APA Style

Tang, P. C.-T., Zhang, Y.-Y., Chan, M. K.-K., Lam, W. W.-Y., Chung, J. Y.-F., Kang, W., To, K.-F., Lan, H.-Y., & Tang, P. M.-K. (2020). The Emerging Role of Innate Immunity in Chronic Kidney Diseases. International Journal of Molecular Sciences, 21(11), 4018. https://doi.org/10.3390/ijms21114018

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