Next Article in Journal
ID1-Mediated BMP Signaling Pathway Potentiates Glucagon-Like Peptide-1 Secretion in Response to Nutrient Replenishment
Next Article in Special Issue
Insight into the Regulatory Relationships between the Insulin-Like Androgenic Gland Hormone Gene and the Insulin-Like Androgenic Gland Hormone-binding Protein Gene in Giant Freshwater Prawns (Macrobrachium rosenbergii)
Previous Article in Journal
Molecular Aspects and Treatment of Iron Deficiency in the Elderly
Previous Article in Special Issue
High Homology-Directed Repair Using Mitosis Phase and Nucleus Localizing Signal
Review

Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis

1
Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges-Lausanne, Switzerland
2
Institut national de recherche et de sécurité (INRS), 54500 Vandœuvre-lès-Nancy, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(11), 3822; https://doi.org/10.3390/ijms21113822
Received: 30 April 2020 / Revised: 25 May 2020 / Accepted: 26 May 2020 / Published: 28 May 2020
(This article belongs to the Collection Feature Papers in Molecular Genetics and Genomics)
Isoprostanes are physiopathologic mediators of oxidative stress, resulting in lipid peroxidation. 8-isoprostane seems particularly useful for measuring oxidative stress damage. However, no reference range values are available for 8-isoprosante in exhaled breath condensate (EBC) of healthy adults, enabling its meaningful interpretation as a biomarker. We conducted this systematic review and meta-analysis according to the protocol following PROSPERO (CRD42020146623). After searching and analyzing the literature, we included 86 studies. After their qualitative synthesis and risk of bias assessment, 52 studies were included in meta-analysis. The latter focused on studies using immunological analytical methods and investigated how the concentrations of 8-isoprostane differ based on gender. We found that gender had no significant effect in 8-isoprostane concentration. Among other studied factors, such as individual characteristics and factors related to EBC collection, only the device used for EBC collection significantly affected measured 8-isoprostane concentrations. However, adjustment for the factors related to EBC collection, yielded uncertainty whether this effect is due to the device itself or to the other factors. Given this uncertainty, we estimated the reference range values of 8-isoprostane stratified by gender and EBC collection device. A better standardization of EBC collection seems necessary; as well more studies using chemical analytical methods to extend this investigation. View Full-Text
Keywords: 8-isoprostane; lung; inflammation; oxidative stress; exhaled air; reference range; healthy adult; exposure; baseline value; gender 8-isoprostane; lung; inflammation; oxidative stress; exhaled air; reference range; healthy adult; exposure; baseline value; gender
Show Figures

Figure 1

MDPI and ACS Style

Shoman, Y.; Wild, P.; Hemmendinger, M.; Graille, M.; Sauvain, J.-J.; B. Hopf, N.; Guseva Canu, I. Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2020, 21, 3822. https://doi.org/10.3390/ijms21113822

AMA Style

Shoman Y, Wild P, Hemmendinger M, Graille M, Sauvain J-J, B. Hopf N, Guseva Canu I. Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2020; 21(11):3822. https://doi.org/10.3390/ijms21113822

Chicago/Turabian Style

Shoman, Yara, Pascal Wild, Maud Hemmendinger, Melanie Graille, Jean-Jacques Sauvain, Nancy B. Hopf, and Irina Guseva Canu. 2020. "Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 21, no. 11: 3822. https://doi.org/10.3390/ijms21113822

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop