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Open AccessArticle

The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study

1
Department of Oral and Craniomaxillofacial Surgery, Center for Dental Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany
2
Department of Prosthodontics, Julius-Maximilians-University, 97070 Würzburg, Germany
3
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
4
Department of Laboratory Animal Science, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
5
Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital Aachen (RWTH), 52074 Aachen, Germany
6
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, 14197 Berlin, Germany
7
Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3616; https://doi.org/10.3390/ijms21103616
Received: 19 April 2020 / Revised: 13 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM Inspect 2018 (GOM, Braunschweig). After 16 weeks, the lower jaws were prepared and examined using standard histological methods. In the test group (BEGO OSS + pamidronate), buccooral dimensional loss was significantly lower, both vestibulary (−0.80 ± 0.57 mm vs. −1.92 ± 0.63 mm; p = 0.00298) and lingually (−1.36 ± 0.58 mm vs. −2.56 ± 0.65 mm; p = 0.00104) compared with the control group (BEGO OSS). The test group showed a significant difference between vestibular and lingual dimensional loss (p = 0.04036). Histology showed cortical and cancellous bone in the alveolar sockets without signs of local inflammation. Adjuvant application of pamidronate during socket preservation reduces alveolar dimensional loss significantly. Further investigations with regard to dose–response relationships, volume effects, side effects, and a verification of the suitability in combination with other bone substitute materials (BSMs) are necessary. View Full-Text
Keywords: pamidronate; socket preservation; ridge preservation; bone remodeling; bone regeneration; bisphosphonates pamidronate; socket preservation; ridge preservation; bone remodeling; bone regeneration; bisphosphonates
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MDPI and ACS Style

Kauffmann, F.; Höhne, C.; Assaf, A.T.; Vollkommer, T.; Semmusch, J.; Reitmeier, A.; Michel Stein, J.; Heiland, M.; Smeets, R.; Rutkowski, R. The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study. Int. J. Mol. Sci. 2020, 21, 3616. https://doi.org/10.3390/ijms21103616

AMA Style

Kauffmann F, Höhne C, Assaf AT, Vollkommer T, Semmusch J, Reitmeier A, Michel Stein J, Heiland M, Smeets R, Rutkowski R. The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study. International Journal of Molecular Sciences. 2020; 21(10):3616. https://doi.org/10.3390/ijms21103616

Chicago/Turabian Style

Kauffmann, Frederic; Höhne, Christian; Assaf, Alexandre T.; Vollkommer, Tobias; Semmusch, Jan; Reitmeier, Aline; Michel Stein, Jamal; Heiland, Max; Smeets, Ralf; Rutkowski, Rico. 2020. "The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study" Int. J. Mol. Sci. 21, no. 10: 3616. https://doi.org/10.3390/ijms21103616

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