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Review

RNA-Binding Proteins in Acute Leukemias

1
Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany
2
Institute of Molecular Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3409; https://doi.org/10.3390/ijms21103409
Received: 21 April 2020 / Revised: 7 May 2020 / Accepted: 10 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue RNA-Binding Proteins in Human Diseases—from Mechanisms to Therapies)
Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions. View Full-Text
Keywords: AML; ALL; hematopoiesis; RNA-binding protein; MSI2; IGF2BP; RBM15-MKL1; hnRNP K; nucleolin; ZFP36; WT1; CPSF6 AML; ALL; hematopoiesis; RNA-binding protein; MSI2; IGF2BP; RBM15-MKL1; hnRNP K; nucleolin; ZFP36; WT1; CPSF6
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MDPI and ACS Style

Schuschel, K.; Helwig, M.; Hüttelmaier, S.; Heckl, D.; Klusmann, J.-H.; Hoell, J.I. RNA-Binding Proteins in Acute Leukemias. Int. J. Mol. Sci. 2020, 21, 3409. https://doi.org/10.3390/ijms21103409

AMA Style

Schuschel K, Helwig M, Hüttelmaier S, Heckl D, Klusmann J-H, Hoell JI. RNA-Binding Proteins in Acute Leukemias. International Journal of Molecular Sciences. 2020; 21(10):3409. https://doi.org/10.3390/ijms21103409

Chicago/Turabian Style

Schuschel, Konstantin, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan-Henning Klusmann, and Jessica I. Hoell 2020. "RNA-Binding Proteins in Acute Leukemias" International Journal of Molecular Sciences 21, no. 10: 3409. https://doi.org/10.3390/ijms21103409

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