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Open AccessReview

Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis

by 1,2 and 2,*
1
School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
2
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 90; https://doi.org/10.3390/ijms21010090
Received: 4 December 2019 / Revised: 18 December 2019 / Accepted: 19 December 2019 / Published: 21 December 2019
(This article belongs to the Special Issue Frontiers in the Actin Cytoskeleton)
The actin cytoskeleton is crucially important to maintenance of the cellular structure, cell motility, and endocytosis. Accordingly, bacterial pathogens often co-opt the actin-restructuring machinery of host cells to access or create a favorable environment for their own replication. The obligate intracellular organism Chlamydia trachomatis and related species exemplify this dynamic: by inducing actin polymerization at the site of pathogen-host attachment, Chlamydiae induce their own uptake by the typically non-phagocytic epithelium they infect. The interaction of chlamydial adhesins with host surface receptors has been implicated in this effect, as has the activity of the chlamydial effector TarP (translocated actin recruitment protein). Following invasion, C. trachomatis dynamically assembles and maintains an actin-rich cage around the pathogen’s membrane-bound replicative niche, known as the chlamydial inclusion. Through further induction of actin polymerization and modulation of the actin-crosslinking protein myosin II, C. trachomatis promotes egress from the host via extrusion of the inclusion. In this review, we present the experimental findings that can inform our understanding of actin-dependent chlamydial pathogenesis, discuss lingering questions, and identify potential avenues of future study. View Full-Text
Keywords: actin cytoskeleton; chlamydia; bacterial pathogenesis actin cytoskeleton; chlamydia; bacterial pathogenesis
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MDPI and ACS Style

Caven, L.; Carabeo, R.A. Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis. Int. J. Mol. Sci. 2020, 21, 90. https://doi.org/10.3390/ijms21010090

AMA Style

Caven L, Carabeo RA. Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis. International Journal of Molecular Sciences. 2020; 21(1):90. https://doi.org/10.3390/ijms21010090

Chicago/Turabian Style

Caven, Liam; Carabeo, Rey A. 2020. "Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis" Int. J. Mol. Sci. 21, no. 1: 90. https://doi.org/10.3390/ijms21010090

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