Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells
Abstract
:1. Introduction
2. Overview of Regulatory Mechanisms of DUSP Activity
3. DUSP in Neuronal Differentiation and Nervous System Development
4. DUSP in Neuroprotection; Role of Neurotrophins and Nucleotides
4.1. DUSP Regulation in Excitotoxicity and Oxidative Stress
4.2. DUSP Regulation in Genotoxic Stress
4.3. DUSP in Hypoxia and Ischemia
5. DUSP in Pain and Inflammation; Role of Cannabinoids
6. DUSP in Brain Diseases
6.1. DUSP in Neurodegenerative Diseases
6.2. DUSP in Neurological Disorders
6.3. DUSPs in Brain Tumors
7. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AD | Alzheimer′s disease |
BD | Bipolar disorder |
BDNF | Brain-derived neurotrophic factor |
BzATP | 2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate |
DUSP | Dual-specificity protein phosphatase |
EGF | Epidermal growth factor |
ERK | Extracellular signal regulated protein kinase |
ETS | E twenty-six |
GSK3 | Glycogen synthase kinase 3 |
H2O2 | Hydrogen peroxide |
HD | Huntington′s disease |
JNKs | c-Jun N-terminal kinase |
MAPK | Mitogen-activated protein kinase |
MEK | Mitogen extracellular activated kinase |
NGF | Nerve growth factor |
PD | Parkinson′s disease |
PI3K | Phosphatidylinositol 3-kinase |
PKA | Protein kinase A |
PKC | Protein kinase C |
PTP | Protein tyrosine phosphatase |
TTP | Tristetraprolin |
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Pérez-Sen, R.; Queipo, M.J.; Gil-Redondo, J.C.; Ortega, F.; Gómez-Villafuertes, R.; Miras-Portugal, M.T.; Delicado, E.G. Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells. Int. J. Mol. Sci. 2019, 20, 1999. https://doi.org/10.3390/ijms20081999
Pérez-Sen R, Queipo MJ, Gil-Redondo JC, Ortega F, Gómez-Villafuertes R, Miras-Portugal MT, Delicado EG. Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells. International Journal of Molecular Sciences. 2019; 20(8):1999. https://doi.org/10.3390/ijms20081999
Chicago/Turabian StylePérez-Sen, Raquel, María José Queipo, Juan Carlos Gil-Redondo, Felipe Ortega, Rosa Gómez-Villafuertes, María Teresa Miras-Portugal, and Esmerilda G. Delicado. 2019. "Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells" International Journal of Molecular Sciences 20, no. 8: 1999. https://doi.org/10.3390/ijms20081999