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Int. J. Mol. Sci. 2019, 20(8), 1904; https://doi.org/10.3390/ijms20081904

The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases

, and *
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, Guangdong 510006, China
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Received: 7 March 2019 / Revised: 14 April 2019 / Accepted: 15 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Traditional Medicine – Unraveling Its Molecular Mechanism, Volume 2)
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Abstract

Autophagy is an evolutionarily conserved ‘self-eating’ process that maintains cellular, tissue, and organismal homeostasis. New studies on autophagy, mediated by subsets of autophagy proteins, are emerging in many physiological and pathological processes. Astragalus membranaceus (AM), also named Huangqi, is one of the fundamental herbs in traditional Chinese medicine and its extracts have been proved to possess many biological activities related to autophagy, including anti-oxidation, anti-inflammation, anticancer, anti-photoaging, and improvement of cardiomyocyte function. Evidence suggests that AM extracts can have therapeutic potential in autophagy dysregulation-associated diseases because of their biological positive effects. Here we will review the literature concerning the effects of AM extracts on autophagy dysregulation-associated diseases. View Full-Text
Keywords: autophagy; Astragalus membranaceus; Astragalus membranaceus extracts; autophagy dysregulation-associated diseases autophagy; Astragalus membranaceus; Astragalus membranaceus extracts; autophagy dysregulation-associated diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Shan, H.; Zheng, X.; Li, M. The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases. Int. J. Mol. Sci. 2019, 20, 1904.

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