Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration
AbstractUbiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases. View Full-Text
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Jantrapirom, S.; Lo Piccolo, L.; Yamaguchi, M. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Int. J. Mol. Sci. 2019, 20, 1893.
Jantrapirom S, Lo Piccolo L, Yamaguchi M. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. International Journal of Molecular Sciences. 2019; 20(8):1893.Chicago/Turabian Style
Jantrapirom, Salinee; Lo Piccolo, Luca; Yamaguchi, Masamitsu. 2019. "Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration." Int. J. Mol. Sci. 20, no. 8: 1893.
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