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Int. J. Mol. Sci. 2019, 20(8), 1893; https://doi.org/10.3390/ijms20081893

Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration

1
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
2
Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
3
Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan
*
Author to whom correspondence should be addressed.
Received: 27 March 2019 / Revised: 9 April 2019 / Accepted: 15 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Proteostasis and Proteasome Inhibitors)
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Abstract

Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases. View Full-Text
Keywords: UbL-UbA; non-proteasomal ubiquitin receptor; proteostasis; ubiquitin-like; neurodegenerative diseases; Drosophila UbL-UbA; non-proteasomal ubiquitin receptor; proteostasis; ubiquitin-like; neurodegenerative diseases; Drosophila
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Jantrapirom, S.; Lo Piccolo, L.; Yamaguchi, M. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Int. J. Mol. Sci. 2019, 20, 1893.

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