Next Article in Journal
Evaluation of Biological Response of STRO-1/c-Kit Enriched Human Dental Pulp Stem Cells to Titanium Surfaces Treated with Two Different Cleaning Systems
Previous Article in Journal
Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus
Previous Article in Special Issue
Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(8), 1872; https://doi.org/10.3390/ijms20081872

C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression

1
Oral Health Science Research Center, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan
2
Department of Dentomaxillofacial Diagnosis and Treatment, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan
3
Nippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki 302-0017, Japan
4
Department of Oral Function and Molecular Biology, Ohu University School of Dentistry, Koriyama 963-8611, Japan
5
Department of Oral Science, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan
6
Department of Critical Care Medicine and Dentistry, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan
7
Division of Carcinogenesis and Cancer Prevention, Department of Cell Culture Technology, National Cancer Center Research Institute, Tokyo 104-0045, Japan
*
Author to whom correspondence should be addressed.
Received: 5 March 2019 / Revised: 12 April 2019 / Accepted: 12 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Chemokines in Cancer and Inflammatory Diseases)
  |  
PDF [1648 KB, uploaded 16 April 2019]
  |  

Abstract

Cancer is a leading cause of death and disease worldwide, with a tremendous financial impact. Thus, the development of cost-effective novel approaches for suppressing tumor growth and progression is essential. In an attempt to identify the mechanisms responsible for tumor suppression, we screened for molecules downregulated in a cancer progression model and found that the chemokine CXCL14, also called BRAK, was the most significantly downregulated. Increasing the production of CXCL14 protein by transfecting tumor cells with a CXCL14 expression vector and transplanting the cells into the back skin of immunodeficient mice suppressed tumor cell growth compared with that of parental tumor cells, suggesting that CXCL14 suppressed tumor growth in vivo. However, some studies have reported that over-expression of CXCL14, especially in stromal cells, stimulated the progression of tumor formation. Transgenic mice expressing 10-fold more CXCL14 protein than wild-type C57BL/6 mice showed reduced rates of chemical carcinogenesis, transplanted tumor growth, and metastasis without apparent side effects. CXCL14 also acts as an antimicrobial molecule. In this review, we highlight recent studies involving the identification and characterization of CXCL14 in cancer progression and discuss the reasons for the context-dependent effects of CXCL14 on tumor formation. View Full-Text
Keywords: C-X-C motif chemokine ligand 14; multifunctional tumor suppressor; antimicrobial function; molecular preventive medicine C-X-C motif chemokine ligand 14; multifunctional tumor suppressor; antimicrobial function; molecular preventive medicine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Yang, X.-Y.; Ozawa, S.; Kato, Y.; Maehata, Y.; Izukuri, K.; Ikoma, T.; Kanamori, K.; Akasaka, T.; Suzuki, K.; Iwabuchi, H.; Kurata, S.-I.; Katoh, I.; Sakurai, T.; Kiyono, T.; Hata, R.-I. C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression. Int. J. Mol. Sci. 2019, 20, 1872.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top