Superantigenic Activation of Human Cardiac Mast Cells
Abstract
:1. Introduction
2. Results
2.1. Effect of Human IgG Anti-IgE on Mediator Release from HHMCs
2.2. Effect of Bacterial Superantigens on Mediator Release from HHMCs
2.3. Effect of Viral Superantigens on Mediator Release from HHMCs
3. Discussion
4. Materials and Methods
4.1. Reagents
4.2. Buffers
4.3. Human Monoclonal IgM and IgE and Human Polyclonal IgG
4.4. Isolation of HHMCs
4.5. Histamine Release Assay
4.6. Immunoassay of LTC4 and PGD2
4.7. VEGF-A and VEGF-C Release
4.8. Statistical Analysis
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
S. aureus | Staphylococcus aureus |
P. magnus | Peptostreptococcus magnus |
LTC4 | Cysteinyl leukotriene C4 |
HHMCs | Human heart mast cells |
Ig | Immunoglobulin |
FcεRI | High-affinity receptor for IgE |
PGD2 | Prostaglandin D2 |
gp120 | Glycoprotein 120 |
VEGF | Vascular endothelial growth factor |
SAg | Superantigen |
APCs | Antigen-presenting cells |
MHC | Major histocompatibility complex |
TCR | T cell receptor |
V | Variable |
H | Heavy |
L | Light |
SE | Staphylococcus aureus enterotoxins |
IL | Interleukin |
HIV | Human immunodeficiency virus |
FCS | Fetal calf serum |
BSA | Bovine serum albumin |
H-aIgE | Human IgG anti-IgE |
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Varricchi, G.; Loffredo, S.; Borriello, F.; Pecoraro, A.; Rivellese, F.; Genovese, A.; Spadaro, G.; Marone, G. Superantigenic Activation of Human Cardiac Mast Cells. Int. J. Mol. Sci. 2019, 20, 1828. https://doi.org/10.3390/ijms20081828
Varricchi G, Loffredo S, Borriello F, Pecoraro A, Rivellese F, Genovese A, Spadaro G, Marone G. Superantigenic Activation of Human Cardiac Mast Cells. International Journal of Molecular Sciences. 2019; 20(8):1828. https://doi.org/10.3390/ijms20081828
Chicago/Turabian StyleVarricchi, Gilda, Stefania Loffredo, Francesco Borriello, Antonio Pecoraro, Felice Rivellese, Arturo Genovese, Giuseppe Spadaro, and Gianni Marone. 2019. "Superantigenic Activation of Human Cardiac Mast Cells" International Journal of Molecular Sciences 20, no. 8: 1828. https://doi.org/10.3390/ijms20081828