An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer
AbstractThe selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy. Therefore, specific antibodies against CD137 are being studied and developed aiming to activate and enhance anti-cancer immune responses as well as suppress oncogenic cells. Accumulating evidence suggests that anti-CD137 antibodies can be used separately to prevent tumor in some cases, while in other cases, these antibodies need to be co-administered with other antibodies or drugs/vaccines/regents for a better performance. Thus, in this work, we aim to update and discuss current knowledge about anti-cancer effects of anti-CD137 antibodies as mono- and combined-immunotherapies. View Full-Text
Share & Cite This Article
Chu, D.-T.; Bac, N.D.; Nguyen, K.-H.; Tien, N.L.B.; Thanh, V.V.; Nga, V.T.; Ngoc, V.T.N.; Anh Dao, D.T.; Hoan, L.N.; Hung, N.P.; Trung Thu, N.T.; Pham, V.-H.; Vu, L.N.; Pham, T.A.V.; Thimiri Govinda Raj, D.B. An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer. Int. J. Mol. Sci. 2019, 20, 1822.
Chu D-T, Bac ND, Nguyen K-H, Tien NLB, Thanh VV, Nga VT, Ngoc VTN, Anh Dao DT, Hoan LN, Hung NP, Trung Thu NT, Pham V-H, Vu LN, Pham TAV, Thimiri Govinda Raj DB. An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer. International Journal of Molecular Sciences. 2019; 20(8):1822.Chicago/Turabian Style
Chu, Dinh-Toi; Bac, Nguyen D.; Nguyen, Khanh-Hoang; Tien, Nguyen L.B.; Thanh, Vo V.; Nga, Vu T.; Ngoc, Vo T.N.; Anh Dao, Duong T.; Hoan, Le N.; Hung, Nguyen P.; Trung Thu, Nguyen T.; Pham, Van-Huy; Vu, Le N.; Pham, Thuy A.V.; Thimiri Govinda Raj, Deepak B. 2019. "An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer." Int. J. Mol. Sci. 20, no. 8: 1822.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.