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Int. J. Mol. Sci. 2019, 20(8), 1814; https://doi.org/10.3390/ijms20081814

Virus-Like Particle Facilitated Deposition of Hydroxyapatite Bone Mineral on Nanocellulose after Exposure to Phosphate and Calcium Precursors

1
A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow 119991, Russia
2
A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia
3
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 119991, Russia
4
Cell and Molecular Sciences, The James Hutton Institute, Dundee DD2 5DA, UK
5
CelluComp Ltd., Unit 3, West Dock, Harbour Place, Burntisland KY3 9DW, UK
6
Physical Faculty, Lomonosov Moscow State University, Moscow 119991, Russia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 14 March 2019 / Revised: 4 April 2019 / Accepted: 9 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Plant Viruses and Virus-Induced Diseases)
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Abstract

We produced and isolated tobacco mosaic virus-like particles (TMV VLPs) from bacteria, which are devoid of infectious genomes, and found that they have a net negative charge and can bind calcium ions. Moreover, we showed that the TMV VLPs could associate strongly with nanocellulose slurry after a simple mixing step. We sequentially exposed nanocellulose alone or slurries mixed with the TMV VLPs to calcium and phosphate salts and utilized physicochemical approaches to demonstrate that bone mineral (hydroxyapatite) was deposited only in nanocellulose mixed with the TMV VLPs. The TMV VLPs confer mineralization properties to the nanocellulose for the generation of new composite materials. View Full-Text
Keywords: plant virus; structure; biotechnology; mineralization; composite materials plant virus; structure; biotechnology; mineralization; composite materials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sinitsyna, O.V.; Makarov, V.V.; McGeachy, K.; Bukharova, T.; Whale, E.; Hepworth, D.; Yaminsky, I.V.; Kalinina, N.O.; Taliansky, M.E.; Love, A.J. Virus-Like Particle Facilitated Deposition of Hydroxyapatite Bone Mineral on Nanocellulose after Exposure to Phosphate and Calcium Precursors. Int. J. Mol. Sci. 2019, 20, 1814.

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