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The Dynamics of the Skin’s Immune System

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1811;
Received: 5 March 2019 / Revised: 9 April 2019 / Accepted: 9 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Inflammatory Skin Conditions 2018)
The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing. View Full-Text
Keywords: skin resident immune cells; skin immune responses; inflammation; wound healing; impaired wound healing; scarring skin resident immune cells; skin immune responses; inflammation; wound healing; impaired wound healing; scarring
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Nguyen, A.V.; Soulika, A.M. The Dynamics of the Skin’s Immune System. Int. J. Mol. Sci. 2019, 20, 1811.

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