A Novel Network-Based Computational Model for Prediction of Potential LncRNA–Disease Association
Abstract
:1. Introduction
2. Results
2.1. Performance Evaluation
2.2. Case Studies
3. Discussion
4. Materials and Methods
4.1. Human lncRNA–Disease Associations
4.2. Gaussian Interaction Profile Kernel Similarity for lncRNAs and Diseases
4.3. Prediction Model of NBLDA
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
LOOCV | leave-one-out cross validation |
FPS | final lncRNA–disease association score matrix |
ROC | receiver operating characteristic |
TPR | true positive rate |
FPR | false positive rate |
AUC | area under the ROC curve |
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Disease | LncRNA | Evidence (PMID) | Rank |
---|---|---|---|
Lung cancer | PVT1 | 26493997,28731781,28972861,27904703,29133127 | 1 |
Lung cancer | NEAT1 | 25818739,29152741,28295289,28615056,29095526 | 2 |
Lung cancer | TUG1 | 28069000,24853421,29277771,28121347,27485439 | 3 |
Lung cancer | XIST | 29130102,29339211,26339353,29337100,28248928 | 4 |
Lung cancer | HULC | 30575912 | 5 |
Lung cancer | LINC-ROR | 28459375,28516515,29028092 | 6 |
Lung cancer | PANDAR | 28121347,25719249 | 7 |
Lung cancer | MIAT | 29487526,28843520,29228680,29795987,27981551 | 8 |
Lung cancer | HNF1A-AS1 | 27981551,29289833 | 9 |
Leukemia | H19 | 15645136,29703210,24685695,28765931,29643943 | 1 |
Leukemia | MALAT1 | 28713913 | 2 |
Leukemia | HOTAIR | 27748863,26622861,27875938,25979172,26261618 | 3 |
Leukemia | MEG3 | 28407691,28190319,19595458,14602737,29029424 | 4 |
Leukemia | PVT1 | 29510227,26545364 | 5 |
Leukemia | GAS5 | 27951730 | 6 |
Leukemia | UCA1 | 27854515,29762824,26053097,29663500 | 7 |
Leukemia | TUG1 | 29654398 | 8 |
Leukemia | XIST | 7981627 | 9 |
Leukemia | SNHG5 | 28861326,29917184 | 10 |
Colorectal cancer | CCAT2 | 29181105,27875818,28838211,26853146,23796952 | 1 |
Colorectal cancer | XIST | 29495975,29137332,17143621,28730777,29484395 | 2 |
Colorectal cancer | BCYRN1 | 30114690 | 3 |
Colorectal cancer | HNF1A-AS1 | 28791380,29145164 | 4 |
Colorectal cancer | MIAT | 29686537 | 5 |
Colorectal cancer | ATB | 25750289 | 6 |
Colorectal cancer | TUSC7 | 27683121,28214867,23680400,28979678 | 10 |
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Liu, Y.; Feng, X.; Zhao, H.; Xuan, Z.; Wang, L. A Novel Network-Based Computational Model for Prediction of Potential LncRNA–Disease Association. Int. J. Mol. Sci. 2019, 20, 1549. https://doi.org/10.3390/ijms20071549
Liu Y, Feng X, Zhao H, Xuan Z, Wang L. A Novel Network-Based Computational Model for Prediction of Potential LncRNA–Disease Association. International Journal of Molecular Sciences. 2019; 20(7):1549. https://doi.org/10.3390/ijms20071549
Chicago/Turabian StyleLiu, Yang, Xiang Feng, Haochen Zhao, Zhanwei Xuan, and Lei Wang. 2019. "A Novel Network-Based Computational Model for Prediction of Potential LncRNA–Disease Association" International Journal of Molecular Sciences 20, no. 7: 1549. https://doi.org/10.3390/ijms20071549