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Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine

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Int. J. Mol. Sci. 2019, 20(6), 1270; https://doi.org/10.3390/ijms20061270
Received: 1 February 2019 / Revised: 6 March 2019 / Accepted: 8 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Glutamate Receptors in Health and Disease)
Numerous studies have demonstrated the antidepressant effects of group II metabotropic glutamate (mGlu2/3) receptor antagonists in various rodent models. Importantly, it has been shown that the antidepressant effects of mGlu2/3 receptor antagonists in rodent models are similar to those of ketamine, which exerts rapid and long-lasting antidepressant effects in patients with major depressive disorders, including patients with treatment-resistant depression. In addition, the synaptic mechanisms underlying the effects of mGlu2/3 receptor antagonists are reported to be similar to those underlying the effects of ketamine. The roles of the serotonergic system in the antidepressant effects of mGlu2/3 receptor antagonists have recently been demonstrated. Moreover, it was investigated how mGlu2/3 receptor antagonists interact with the serotonergic system to exert antidepressant effects. Notably, the same neural mechanisms as those underlying the effects of ketamine may be involved in the antidepressant actions of the mGlu2/3 receptor antagonists. In this review, we shall summarize the antidepressant potential of mGlu2/3 receptor antagonists and their mechanisms of action in comparison with those of ketamine. In particular, we shall focus on the roles of the serotonergic system in the antidepressant actions of mGlu2/3 receptor antagonists. View Full-Text
Keywords: mGlu2/3 receptor antagonist; ketamine; antidepressant; serotonin; 5-HT1A receptor; medial prefrontal cortex; AMPA receptor mGlu2/3 receptor antagonist; ketamine; antidepressant; serotonin; 5-HT1A receptor; medial prefrontal cortex; AMPA receptor
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MDPI and ACS Style

Chaki, S.; Fukumoto, K. Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine. Int. J. Mol. Sci. 2019, 20, 1270. https://doi.org/10.3390/ijms20061270

AMA Style

Chaki S, Fukumoto K. Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine. International Journal of Molecular Sciences. 2019; 20(6):1270. https://doi.org/10.3390/ijms20061270

Chicago/Turabian Style

Chaki, Shigeyuki, and Kenichi Fukumoto. 2019. "Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine" International Journal of Molecular Sciences 20, no. 6: 1270. https://doi.org/10.3390/ijms20061270

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