Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
Renata Novak Kujundžić 1, Višnja Stepanić 1
, Lidija Milković 2, Ana Čipak Gašparović 2, Marko Tomljanović 1 and Koraljka Gall Trošelj 1,*
, Lidija Milković 2, Ana Čipak Gašparović 2, Marko Tomljanović 1 and Koraljka Gall Trošelj 1,*
1
Laboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia
2
Laboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(5), 1180; https://doi.org/10.3390/ijms20051180
Received: 25 January 2019 / Revised: 1 March 2019 / Accepted: 5 March 2019 / Published: 8 March 2019
(This article belongs to the Special Issue Curcumin in Health and Disease)
Abstract
Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti-inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century. View Full-TextKeywords:
curcumin; oxidative metabolites; inflamm-aging; cancer; metabolic reprogramming; direct protein binding; IL-17; STAT3; SHMT2
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Kujundžić, R.N.; Stepanić, V.; Milković, L.; Gašparović, A.Č.; Tomljanović, M.; Trošelj, K.G. Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. Int. J. Mol. Sci. 2019, 20, 1180.
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