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Int. J. Mol. Sci. 2019, 20(3), 763;

Covalently-Linked Hyaluronan versus Acid Etched Titanium Dental Implants: A Crossover RCT in Humans

Department of Clinico-Surgical, Diagnostic and Pediatric Sciences, Dental Clinic, University of Pavia, P.le Golgi 2, 27100 Pavia, Italy
Nobil Bio Ricerche srl, V. Valcastellana 26, 14037 Portacomaro, Italy
Private Practice, V. Vincenzo Ussani 86, 00151 Roma, Italy
Author to whom correspondence should be addressed.
Received: 30 December 2018 / Revised: 24 January 2019 / Accepted: 6 February 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Molecular Research on Dental Materials and Biomaterials 2018)
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Biochemical modification of titanium surfaces (BMTiS) entails immobilization of biomolecules to implant surfaces in order to induce specific host responses. This crossover randomized clinical trial assesses clinical success and marginal bone resorption of dental implants bearing a surface molecular layer of covalently-linked hyaluronan in comparison with control implants up to 36 months after loading. Patients requiring bilateral implant rehabilitation received hyaluronan covered implants in one side of the mouth and traditional implants in the other side. Two months after the first surgery, a second surgery was undergone to uncover the screw and to place a healing abutment. After two weeks, the operator proceeded with prosthetic procedures. Implants were evaluated by periapical radiographs and the crestal bone level was recorded at mesial and distal sites—at baseline and up to 36 months. One hundred and six implants were positioned, 52 HY-coated, and 48 controls were followed up. No differences were observed in terms of insertion and stability, wound healing, implant success, and crestal bone resorption at any time considered. All interventions had an optimal healing, and no adverse events were recorded. This trial shows, for the first time, a successful use in humans of biochemical-modified implants in routine clinical practice and in healthy patients and tissues with satisfactory outcomes. View Full-Text
Keywords: dental implants; surface modification; hyaluronan; clinical trial dental implants; surface modification; hyaluronan; clinical trial

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lupi, S.M.; Rodriguez y Baena, A.; Cassinelli, C.; Iviglia, G.; Tallarico, M.; Morra, M.; Rodriguez y Baena, R. Covalently-Linked Hyaluronan versus Acid Etched Titanium Dental Implants: A Crossover RCT in Humans. Int. J. Mol. Sci. 2019, 20, 763.

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