Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma
AbstractSarcopenia, which represents the degenerative and systemic loss of skeletal muscle mass, is a multifactorial syndrome caused by various clinical conditions. Sarcopenia reflects not only frailty and poor general health status, but also the possible presence of advanced or progressive cancer or cancer cachexia. Therefore, sarcopenia affects the management of cancer-bearing patients, including those with urothelial carcinoma. Recently, growing evidence has shown that sarcopenia is significantly associated with higher rates of treatment-related complications and worse prognosis in patients with urothelial carcinoma, including muscle-invasive bladder cancer, upper tract urothelial carcinoma, and advanced urothelial carcinoma. Moreover, several studies reported that a post-therapeutic increase in skeletal muscle mass predicts favorable prognosis in urothelial carcinoma patients. To further explore the role of sarcopenia in the management of urothelial carcinoma patients, comprehensive understanding of its pathophysiology is vital. In this article, we reviewed the metabolic and molecular basis of cancer cachexia and sarcopenia. From this viewpoint, we discussed the possible mechanism of changes in skeletal muscle mass during the course of treatment. View Full-Text
Share & Cite This Article
Fukushima, H.; Fujii, Y.; Koga, F. Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma. Int. J. Mol. Sci. 2019, 20, 760.
Fukushima H, Fujii Y, Koga F. Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma. International Journal of Molecular Sciences. 2019; 20(3):760.Chicago/Turabian Style
Fukushima, Hiroshi; Fujii, Yasuhisa; Koga, Fumitaka. 2019. "Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma." Int. J. Mol. Sci. 20, no. 3: 760.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.