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Int. J. Mol. Sci. 2019, 20(3), 731; https://doi.org/10.3390/ijms20030731

Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia

1
Pharmgenetix GmbH, A-5081 Niederalm, Austria
2
Institute of Pharmacology and Toxicology, Paracelsus Medical University, A-5020 Salzburg, Austria
3
Department of Personalized Medicine, Humanomed, A-9020 Klagenfurt, Austria
*
Author to whom correspondence should be addressed.
Received: 13 December 2018 / Revised: 29 January 2019 / Accepted: 29 January 2019 / Published: 9 February 2019
(This article belongs to the Special Issue The Interleukins in Health and Disease)
Full-Text   |   PDF [1042 KB, uploaded 9 February 2019]   |  

Abstract

Pendrin (SLC26A4), a Cl/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during inflammatory diseases leads to imbalances in airway surface liquid thickness and mucin release, while, in the esophageal epithelium, dysregulated pendrin expression is supposed to impact the intracellular pH regulation system. In this review, we discuss some of the recent findings on interleukin-mediated transcriptional regulation of pendrin and how this dysregulation impacts airway and esophagus epithelial homeostasis during inflammatory diseases. View Full-Text
Keywords: pendrin; interleukins; airway epithelium; esophageal epithelium; asthma; eosinophilic esophagitis pendrin; interleukins; airway epithelium; esophageal epithelium; asthma; eosinophilic esophagitis
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Vanoni, S.; Scantamburlo, G.; Dossena, S.; Paulmichl, M.; Nofziger, C. Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia. Int. J. Mol. Sci. 2019, 20, 731.

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