Next Article in Journal
Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells
Next Article in Special Issue
Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia
Previous Article in Journal
Combining TIR and FRET in Molecular Test Systems
Previous Article in Special Issue
Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan

Interleukin-18 in Health and Disease

Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 649;
Received: 21 December 2018 / Revised: 28 January 2019 / Accepted: 29 January 2019 / Published: 2 February 2019
(This article belongs to the Special Issue The Interleukins in Health and Disease)
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12 is a commitment factor that induces the development of Th1 cells. In contrast, IL-18 is a proinflammatory cytokine that facilitates type 1 responses. However, IL-18 without IL-12 but with IL-2, stimulates NK cells, CD4+ NKT cells, and established Th1 cells, to produce IL-3, IL-9, and IL-13. Furthermore, together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Therefore, IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. IL-18 is a member of the IL-1 family of cytokines. IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. In this review article, we will focus on the unique features of IL-18 in health and disease in experimental animals and humans. View Full-Text
Keywords: IFN-γ; Inflammation; host defense; disease; innate-type allergy; therapeutic target IFN-γ; Inflammation; host defense; disease; innate-type allergy; therapeutic target
Show Figures

Figure 1

MDPI and ACS Style

Yasuda, K.; Nakanishi, K.; Tsutsui, H. Interleukin-18 in Health and Disease. Int. J. Mol. Sci. 2019, 20, 649.

AMA Style

Yasuda K, Nakanishi K, Tsutsui H. Interleukin-18 in Health and Disease. International Journal of Molecular Sciences. 2019; 20(3):649.

Chicago/Turabian Style

Yasuda, Koubun, Kenji Nakanishi, and Hiroko Tsutsui. 2019. "Interleukin-18 in Health and Disease" International Journal of Molecular Sciences 20, no. 3: 649.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop