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Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches

1
Chemistry Department, Amazonas Federal University, Av. Rodrigo Octavio, 6200, Manaus AM 69080-900, Brazil
2
Department of Pharmacy, Federal University of Rio Grande do Norte, Natal RN 59012-570, Brazil
3
Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
4
Military Institute of Engineering, Praça General Tiburcio, 80, Praia Vermelha, Rio de Janeiro RJ 22290-290, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 642; https://doi.org/10.3390/ijms20030642
Received: 20 November 2018 / Revised: 21 December 2018 / Accepted: 27 December 2018 / Published: 2 February 2019
(This article belongs to the Section Biochemistry)
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Abstract

This review aims to provide a critical review of the biological performance of natural and synthetic substances complexed with cyclodextrins, highlighting: (i) inclusion complexes with cyclodextrins and their biological studies in vitro and in vivo; (ii) Evaluation and comparison of the bioactive efficacy of complexed and non-complexed substances; (iii) Chemical and biological performance tests of inclusion complexes, aimed at the development of new pharmaceutical products. Based on the evidence presented in the review, it is clear that cyclodextrins play a vital role in the development of inclusion complexes which promote improvements in the chemical and biological properties of the complexed active principles, as well as providing improved solubility and aqueous stability. Although the literature shows the importance of their ability to help produce innovative biotechnological substances, we still need more studies to develop and expand their therapeutic properties. It is, therefore, very important to gather together evidence of the effectiveness of inclusion complexes with cyclodextrins in order to facilitate a better understanding of research on this topic and encourage further studies. View Full-Text
Keywords: cyclodextrins; substances; inclusion complexes; pharmaceutical technology; biological assays; drug delivery cyclodextrins; substances; inclusion complexes; pharmaceutical technology; biological assays; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Carneiro, S.B.; Costa Duarte, F.Í.; Heimfarth, L.; Siqueira Quintans, J.S.; Quintans-Júnior, L.J.; Veiga Júnior, V.F.; Neves de Lima, Á.A. Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches. Int. J. Mol. Sci. 2019, 20, 642.

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