Next Article in Journal
The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids
Previous Article in Journal
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines
Previous Article in Special Issue
Transplantation of Adipose Stromal Cell Sheet Producing Hepatocyte Growth Factor Induces Pleiotropic Effect in Ischemic Skeletal Muscle
Open AccessReview

Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

1
Department of Intelligent Orthopaedic System Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
2
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
3
Nano Medical Engineering Laboratory, RIKEN, Saitama 351-0198, Japan
4
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(23), 6078; https://doi.org/10.3390/ijms20236078
Received: 27 October 2019 / Revised: 18 November 2019 / Accepted: 29 November 2019 / Published: 2 December 2019
(This article belongs to the Special Issue Hepatocyte Growth Factor (HGF), II)
Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy. View Full-Text
Keywords: hepatocyte growth factor; spinal cord injury; neural regeneration hepatocyte growth factor; spinal cord injury; neural regeneration
Show Figures

Figure 1

MDPI and ACS Style

Yamane, K.; Misawa, H.; Takigawa, T.; Ito, Y.; Ozaki, T.; Matsukawa, A. Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury. Int. J. Mol. Sci. 2019, 20, 6078.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop