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Combination Radioimmunotherapy Strategies for Solid Tumors

by Javeria Zaheer 1,2,†, Hyeongi Kim 1,†, Yong-Jin Lee 1, Jin Su Kim 1,2,* and Sang Moo Lim 1
1
Division of RI application, Korea Institute of Radiological and Medical Sciences, (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea
2
Radiological and Medico-Oncological Sciences, University of Science and Technology (UST), 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5579; https://doi.org/10.3390/ijms20225579
Received: 12 October 2019 / Revised: 31 October 2019 / Accepted: 6 November 2019 / Published: 8 November 2019
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Combination radioimmunotherapy is an emerging approach for the treatment of solid tumors where radio immunotherapy alone has proven to be reasonably ineffective. Radioimmunotherapy (RIT) using monoclonal antibodies (mAbs) labeled with radionuclides is an attractive approach for cancer treatment because tumor-associated mAbs with cytotoxic radionuclides can selectively bind to tumor antigens. However, due to various limitations, mAbs cannot reach solid tumors, consequently reducing RIT efficacy. Combination RIT is a pragmatic approach through which the addition of drugs or other agents not only help mAbs to reach the targeted site but also improves its efficacy. Thus, the combination of drugs or moieties with RIT can be applied to overcome the barriers that RIT faces for solid tumors. This review covers the RIT approach, along with the mechanism of action of mAb used in RIT, limitations of solid tumors, and strategies that can be used in combination RIT to enhance the treatment regimen for solid tumors. View Full-Text
Keywords: radioimmunotherapy; solid tumors; monoclonal antibody; extracellular matrix; cell-to-cell junctions; interstitial pressure; immune suppressive environment radioimmunotherapy; solid tumors; monoclonal antibody; extracellular matrix; cell-to-cell junctions; interstitial pressure; immune suppressive environment
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MDPI and ACS Style

Zaheer, J.; Kim, H.; Lee, Y.-J.; Kim, J.S.; Lim, S.M. Combination Radioimmunotherapy Strategies for Solid Tumors. Int. J. Mol. Sci. 2019, 20, 5579.

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