Next Article in Journal
Degradation of High Energy Materials Using Biological Reduction: A Rational Way to Reach Bioremediation
Previous Article in Journal
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Article

Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts

Science & Engineering Bldg, Faculty of Cosmetics and Beauty biotechnology, Semyung University, 65 Semyung-ro, Jecheon, Chungbuk 390-711, Korea
Int. J. Mol. Sci. 2019, 20(22), 5555; https://doi.org/10.3390/ijms20225555
Received: 30 September 2019 / Revised: 29 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Section Molecular Biology)
Collagen type I production decreases with aging, leading to wrinkles and impaired skin function. Prostaglandin E2 (PGE2), a lipid-derived signaling molecule produced from arachidonic acid by cyclo-oxygenase, inhibits collagen production, and induces matrix metallopeptidase 1 (MMP1) expression by fibroblasts in vitro. PGE2-induced collagen expression inhibition and MMP1 promotion are aging mechanisms. This study investigated the role of E-prostanoid 1 (EP1) in PGE2 signaling in normal human dermal fibroblasts (NHDFs). When EP1 expression was inhibited by EP1 small interfering RNA (siRNA), there were no significant changes in messenger RNA (mRNA) levels of collagen, type I, alpha 1 (COL1A1)/MMP1 between siRNA-transfected NHDFs and siRNA-transfected NHDFs with PGE2. This result showed that EP1 is a PGE2 receptor. Extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after PGE2 treatment significantly increased by ~2.5 times. In addition, PGE2 treatment increased the intracellular Ca2+ concentration in NHDFs. These results indicated that PGE2 is directly associated with EP1 pathway-regulated ERK1/2 and inositol trisphosphate (IP3) signaling in NHDFs. View Full-Text
Keywords: PGE2; EP1; skin-aging; ERK1/2; intracellular calcium PGE2; EP1; skin-aging; ERK1/2; intracellular calcium
Show Figures

Figure 1

MDPI and ACS Style

Shim, J.H. Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts. Int. J. Mol. Sci. 2019, 20, 5555. https://doi.org/10.3390/ijms20225555

AMA Style

Shim JH. Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts. International Journal of Molecular Sciences. 2019; 20(22):5555. https://doi.org/10.3390/ijms20225555

Chicago/Turabian Style

Shim, Joong H. 2019. "Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts" Int. J. Mol. Sci. 20, no. 22: 5555. https://doi.org/10.3390/ijms20225555

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop