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Review

Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer

Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(21), 5252; https://doi.org/10.3390/ijms20215252
Received: 18 September 2019 / Revised: 18 October 2019 / Accepted: 20 October 2019 / Published: 23 October 2019
The awareness of genome complexity brought a radical approach to the study of transcriptome, opening eyes to single RNAs generated from two or more adjacent genes according to the present consensus. This kind of transcript was thought to originate only from chromosomal rearrangements, but the discovery of readthrough transcription opens the doors to a new world of fusion RNAs. In the last years many possible intergenic cis-splicing mechanisms have been proposed, unveiling the origins of transcripts that contain some exons of both the upstream and downstream genes. In some cases, alternative mechanisms, such as trans-splicing and transcriptional slippage, have been proposed. Five databases, containing validated and predicted Fusion Transcripts of Adjacent Genes (FuTAGs), are available for the scientific community. A comparative analysis revealed that two of them contain the majority of the results. A complete analysis of the more widely characterized FuTAGs is provided in this review, including their expression pattern in normal tissues and in cancer. Gene structure, intergenic splicing patterns and exon junction sequences have been determined and here reported for well-characterized FuTAGs. The available functional data and the possible roles in cancer progression are discussed. View Full-Text
Keywords: FuTAG; Cis-SAGe; readthrough; fusion transcript; alternative transcription; cancer FuTAG; Cis-SAGe; readthrough; fusion transcript; alternative transcription; cancer
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MDPI and ACS Style

Barresi, V.; Cosentini, I.; Scuderi, C.; Napoli, S.; Di Bella, V.; Spampinato, G.; Condorelli, D.F. Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer. Int. J. Mol. Sci. 2019, 20, 5252. https://doi.org/10.3390/ijms20215252

AMA Style

Barresi V, Cosentini I, Scuderi C, Napoli S, Di Bella V, Spampinato G, Condorelli DF. Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer. International Journal of Molecular Sciences. 2019; 20(21):5252. https://doi.org/10.3390/ijms20215252

Chicago/Turabian Style

Barresi, Vincenza, Ilaria Cosentini, Chiara Scuderi, Salvatore Napoli, Virginia Di Bella, Giorgia Spampinato, and Daniele F. Condorelli 2019. "Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer" International Journal of Molecular Sciences 20, no. 21: 5252. https://doi.org/10.3390/ijms20215252

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