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Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence
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PPARγ and Cognitive Performance

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5068;
Received: 30 September 2019 / Revised: 9 October 2019 / Accepted: 10 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue PPARs in Metabolic Regulation: Implications for Health and Disease)
Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed. View Full-Text
Keywords: PPAR gamma; Parkinson’s disease; Alzheimer’s disease; autism; schizophrenia; Huntington; PPARγ agonists PPAR gamma; Parkinson’s disease; Alzheimer’s disease; autism; schizophrenia; Huntington; PPARγ agonists
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d’Angelo, M.; Castelli, V.; Catanesi, M.; Antonosante, A.; Dominguez-Benot, R.; Ippoliti, R.; Benedetti, E.; Cimini, A. PPARγ and Cognitive Performance. Int. J. Mol. Sci. 2019, 20, 5068.

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