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Open AccessReview

Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases

1
Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, 1070 Brussels, Belgium
2
Department of Gastroenterology, Hepatology and Digestive Oncology, Hôpital Erasme, Université Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium
3
Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5052; https://doi.org/10.3390/ijms20205052
Received: 19 September 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Channels and Transporters in Cells and Tissues)
Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer. Aquaporins may represent useful drug targets for the treatment of pathophysiological conditions affecting pancreatic function, and/or diagnostic/predictive biomarker for pancreatic cancer. This review summarizes the current knowledge related to the involvement of aquaporins in the pancreas physiology and physiopathology.
Keywords: aquaporins; pancreas; pancreatitis; cancer aquaporins; pancreas; pancreatitis; cancer
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MDPI and ACS Style

Arsenijevic, T.; Perret, J.; Laethem, J.-L.; Delporte, C. Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases. Int. J. Mol. Sci. 2019, 20, 5052.

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