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Effects of Omega-3 Fatty Acids on Immune Cells

Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
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Int. J. Mol. Sci. 2019, 20(20), 5028; https://doi.org/10.3390/ijms20205028
Received: 6 September 2019 / Revised: 27 September 2019 / Accepted: 2 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease: New Knowledge 2019)
Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although the mechanisms for such regulation are diverse. First, as a constitutive part of the cellular membrane, omega-3 fatty acids can regulate cellular membrane properties, such as membrane fluidity or complex assembly in lipid rafts. In recent years, however, a new role for omega-3 fatty acids and their derivatives as signaling molecules has emerged. In this review, we describe the latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms. View Full-Text
Keywords: polyunsaturated fatty acids; PUFAs; omega-3 fatty acids; α-linolenic acid; ALA; eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; immune cells; immune response; phagocytosis; immune-modulation; anti-inflammatory; migration; presentation; cytokines; antibody production polyunsaturated fatty acids; PUFAs; omega-3 fatty acids; α-linolenic acid; ALA; eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; immune cells; immune response; phagocytosis; immune-modulation; anti-inflammatory; migration; presentation; cytokines; antibody production
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Gutiérrez, S.; Svahn, S.L.; Johansson, M.E. Effects of Omega-3 Fatty Acids on Immune Cells. Int. J. Mol. Sci. 2019, 20, 5028.

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