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Omega-3 Polyunsaturated Fatty Acids and Stroke Burden

1
Department of Neurology, Juntendo University Faculty of Medicine, Tokyo 113-8421, Japan
2
Stroke Center and Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(22), 5549; https://doi.org/10.3390/ijms20225549
Received: 12 October 2019 / Revised: 1 November 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease: New Knowledge 2019)
Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke. View Full-Text
Keywords: stroke; omega-3 PUFA; eicosapentaenoic acid; docosahexaenoic acid stroke; omega-3 PUFA; eicosapentaenoic acid; docosahexaenoic acid
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Ueno, Y.; Miyamoto, N.; Yamashiro, K.; Tanaka, R.; Hattori, N. Omega-3 Polyunsaturated Fatty Acids and Stroke Burden. Int. J. Mol. Sci. 2019, 20, 5549.

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