Next Article in Journal
Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides
Previous Article in Journal
Effects of Omega-3 Fatty Acids on Immune Cells
Open AccessReview

Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5029; https://doi.org/10.3390/ijms20205029
Received: 10 September 2019 / Revised: 2 October 2019 / Accepted: 9 October 2019 / Published: 11 October 2019
Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases. View Full-Text
Keywords: autophagy; alcohol-related liver disease; nuclear receptor; ncRNA; non-parenchymal cell autophagy; alcohol-related liver disease; nuclear receptor; ncRNA; non-parenchymal cell
Show Figures

Figure 1

MDPI and ACS Style

Yan, S.; Khambu, B.; Hong, H.; Liu, G.; Huda, N.; Yin, X.-M. Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions. Int. J. Mol. Sci. 2019, 20, 5029.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop