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Ceramide and Regulation of Vascular Tone

Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Ciudad Universitaria S/N, 28040 Madrid, Spain
Ciber Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain
Department of Pediatrics, Maastricht University Medical Center (MUMC+), School for Oncology and Developmental Biology (GROW), 6202 AZ Maastricht, The Netherlands
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(2), 411;
Received: 20 November 2018 / Revised: 2 January 2019 / Accepted: 16 January 2019 / Published: 18 January 2019
(This article belongs to the Special Issue Ceramide)
In addition to playing a role as a structural component of cellular membranes, ceramide is now clearly recognized as a bioactive lipid implicated in a variety of physiological functions. This review aims to provide updated information on the role of ceramide in the regulation of vascular tone. Ceramide may induce vasodilator or vasoconstrictor effects by interacting with several signaling pathways in endothelial and smooth muscle cells. There is a clear, albeit complex, interaction between ceramide and redox signaling. In fact, reactive oxygen species (ROS) activate different ceramide generating pathways and, conversely, ceramide is known to increase ROS production. In recent years, ceramide has emerged as a novel key player in oxygen sensing in vascular cells and mediating vascular responses of crucial physiological relevance such as hypoxic pulmonary vasoconstriction (HPV) or normoxic ductus arteriosus constriction. Likewise, a growing body of evidence over the last years suggests that exaggerated production of vascular ceramide may have detrimental effects in a number of pathological processes including cardiovascular and lung diseases. View Full-Text
Keywords: ceramide; vascular; sphingolipids; reactive oxygen species; oxygen sensing; pulmonary; hypoxic pulmonary vasoconstriction; normoxic ductus arteriosus ceramide; vascular; sphingolipids; reactive oxygen species; oxygen sensing; pulmonary; hypoxic pulmonary vasoconstriction; normoxic ductus arteriosus
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MDPI and ACS Style

Cogolludo, A.; Villamor, E.; Perez-Vizcaino, F.; Moreno, L. Ceramide and Regulation of Vascular Tone. Int. J. Mol. Sci. 2019, 20, 411.

AMA Style

Cogolludo A, Villamor E, Perez-Vizcaino F, Moreno L. Ceramide and Regulation of Vascular Tone. International Journal of Molecular Sciences. 2019; 20(2):411.

Chicago/Turabian Style

Cogolludo, Angel, Eduardo Villamor, Francisco Perez-Vizcaino, and Laura Moreno. 2019. "Ceramide and Regulation of Vascular Tone" International Journal of Molecular Sciences 20, no. 2: 411.

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